Ideals
- Understand and creatively use the language of life.
- Understand and engineer the states of cells.
- Achieve healthy aging and cure neurodegenerative disease.
What I cannot create, I do not understand.
— Richard Feynman
Transcription factors and cofactors, level by level
We map what regulators do at every level, from the protein sequence up to the whole organism, and across species.
- Sequence: The protein sequence a function rests on.
- Biophysics: How proteins meet DNA, RNA and other molecules.
- Gene: How gene expression is regulated, in vitro and in vivo.
- Cell and organism: How whole cell states shift, and what the organism shows.
- Evolution: Comparative genomics, from model organisms to humans.
Regulators designed at scale to change cell states
We design and synthesize regulators for a function, test them in high-throughput perturbation screens, and feed every result back into our models.
- Design and synthesis: Sequences designed for a biological function.
- Perturb and observe: High-throughput perturbation and readout.
- Iterate: Experiments that sharpen knowledge and models each round.
- Engineer: Cell states of aging and disease, changed on purpose.
Knowledge and hypotheses for aging and neurodegeneration
We build a knowledge graph across molecules, cells and organisms, and an AI co-scientist on top of it that proposes the next hypothesis and experiment.
- Knowledge graph: Molecular, cellular and organism data in one graph.
- AI co-scientist: A system that reasons over the graph.
- Next round: Hypotheses, experiment designs and analyses, proposed by AI.
- Toward the clinic: From model organisms and lab systems to patients.