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Liu Lab

Hanqing Liu

Hanqing Liu is a FutureHouse Fellow. From mid-2027 he will lead the Gene Regulation and Design Group at the Interdisciplinary Research Center on Biology and Chemistry, Chinese Academy of Sciences, in Shanghai, which is now being set up. His research integrates large-scale single-cell genomics, molecular technology development and computational modeling to understand how gene regulation is encoded in the genome and deployed across diverse brain cell states. He is particularly interested in activity-dependent gene regulation, and in how non-coding regulatory variation shapes brain development and contributes to psychiatric disorders.

In Joseph Ecker’s lab at the Salk Institute, he led the development of large-scale single-cell brain atlases and multi-omic technologies that revealed how gene regulation organizes neuronal diversity. As a Junior Fellow at Harvard, working with Michael Greenberg’s lab, he developed cell-state-aware genomic foundation models that predict how non-coding genetic variation affects gene regulation across brain cell types and developmental states. Now, as a FutureHouse Fellow, he is building AI-driven frameworks that integrate large-scale single-cell and functional genomics data to reconstruct the regulatory architecture of psychiatric disorders and generate mechanistic hypotheses at scale.

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